%0 Article %J Frontiers in Built Environment %D 2020 %T A Cloud-Enabled Application Framework for Simulating Regional-Scale Impacts of Natural Hazards on the Built Environment %A Deierlein, G. G. %A McKenna, F. %A Zsarnóczay, A. %A Kijewski-Correa, T. %A Kareem, A. %A Elhaddad, W. %A Lowes, L. %A Schoettler, M. J. %A Govindjee, S. %P 196 %V 6 %1 10.3389/fbuil.2020.558706 %K SW4 %X With the goal to facilitate evaluation and mitigation of the risks from natural hazards, the Natural Hazards Engineering Research Infrastructure’s Computational Modeling, and Simulation Center (NHERI SimCenter) is developing computational workflows for regional hazard simulations. These simulations enable research to combine detailed assessments of individual facilities with comprehensive regional-scale simulations of natural hazard effects. By integration of multi-fidelity and multi-resolution models to assess natural hazard impacts on buildings, infrastructure systems and other constructed facilities, the approach enables the engineering analysis of public policies and socio-economic impacts. Effective development of platforms for high-resolution regional simulations requires modular workflows that can integrate state-of-the-art models with information technologies and high-performance computing resources. In this paper, the modular architecture of the computational workflow models is described and illustrated through testbed applications to evaluate regional building damage under an earthquake and a hurricane scenario. Developed and disseminated as open-source software on the NHERI DesignSafe Cyberinfrastructure, the computational models and workflows are enabling multi-disciplinary collaboration on research to mitigate the effects of natural hazard disasters.